lfa-1 program (Sunesis Inc)
90
Structured Review
Sunesis Inc
lfa-1 program
Lfa 1 Program, supplied by Sunesis Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lfa-1+program/lfa+1+program/pm20655213-251-5-3
Average 90 stars, based on 1 article reviews
Lfa 1 Program, supplied by Sunesis Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lfa-1+program/lfa+1+program/pm20655213-251-5-3
Average 90 stars, based on 1 article reviews
lfa-1 program - by Bioz Stars,
2026-09
90/100 stars
Images
Related Articles
other:Article Title: Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Article Snippet: This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1.. In addition to excellent in vitro potency, 6q shows good pharmacokinetic properties and its ethyl ester (6t) demonstrates good oral bioavailability in both mouse and rat.. Either intravenous administration of 6q or oral administration of its ethyl ester (6t) produced a significant reduction of neutrophil migration in a thioglycollate-induced murine peritonitis model. 2010 Elsevier Ltd. All rights reserved. |